French national reference center for rare digestive diseases (MaRDI)
To provide children and their parents with effective and peaceful therapeutic care, the team at the MaRDI reference center has developed a holistic and multi-professional approach as well as 4 therapeutic education programs: parenteral nutrition, enteral nutrition, IBD and transplantation, with at least one coordinating nurse for each.
We work with the main associations of patients and families developed around certain diseases or certain type of care.
We constantly ensure the safety and the best quality of life for children with rare digestive diseases and their families.
The transition to care by adult centers has been organized for several years now with Parisian hospitals (Beaujon, Georges-Pompidou, Saint-Antoine). It is based on anticipation, with, in particular, early transmission of medical information and shared « pediatric-adult » consultations.
Aware of the heaviness of the care and the importance of the issues, we are convinced of the need for care in a center whose expertise is based on years of work and experience in the field.
This reference center is affiliated with the FIMATHO rare diseases healthcare network and the ERNICA European reference network (ERN)
Keywords: Rare digestive diseases, genetic intestinal diseases, home parenteral nutrition, intestinal transplantation, chronic inflammatory bowel disease (IBD), biotherapy.
Medical
team
Pr Frank Ruemmele
MD, PhD
Contact us
Phone. +33 (0) 1 44 49 25 60
or +33 (0) 1 44 49 25 16
The MaRDI reference center was established at Necker hospital in 2004. It was a natural fit, as its gastroenterology and nutrition department had been involved for several decades in the field of rare intestinal diseases, whether those that lead to intestinal insufficiency and require parenteral nutrition (PN) or chronic inflammatory bowel diseases (IBD). Our center is internationally recognised, thanks to scientific communications and publications, but also thanks to the care of children from all over Europe and beyond.
As early as the 1970s, Professor Claude Ricour, faced with serious digestive diseases causing severe malnutrition, developed parenteral nutrition (PN) in France. He initiated its pursuit at home in 1981 leading to the creation, in 1984, in Necker, of the first « expert center for home parenteral nutrition » (HPN) for children. This therapy remains the main means of caring for children with intestinal insufficiency, whether it is linked to a short bowel syndrome, congenital enteropathy or certain neuro-muscular digestive diseases (chronic intestinal pseudo-obstruction, Hirschsprung’s disease). Thanks to a close and long-standing collaboration with the paediatric surgery team (Pr D.Pellerin and Pr Y.Révillon), it was also at Necker that the first intestinal transplant in children was carried out in 1987 and the first liver transplant associated with the intestine was performed in 1994. All these years have been marked by intense research activity which has led to considerable progress in the efficacy and safety of PN. We took an active part in the European Guidelines for PN in children published in 2005 and updated in 2018 in Clinical Nutrition.
The analysis of cohorts of patients with intestinal insufficiency or IBD and clinical research have enabled us to advance therapeutics and to highlight new rare intestinal diseases related to genetic mutations. Thanks to the many skills gathered on the Necker site and to the close links with the Imagine institute, we are continuing this essential research, particularly in molecular genetics with the Immunobiota program for the diagnosis of mutations in children with neonatal onset enteropathies or complex digestive immunopathologies (severe colitis, autoimmune enteropathies, etc.)
In the field of intestinal insufficiency, we have, today in Europe, the largest cohort of children in HPN: 150 children in active line and more than 700 since its initiation at the beginning of the 80’s and the largest series of children having received an intestinal transplant (more than 120 children). For children with short bowel syndrome, we currently have a treatment protocol with a recombinant intestinal hormone, GLP-2.
In the field of IBD, for two decades we have been facing a sharp increase in the incidence and demand for diagnosis (digestive endoscopy, medical imaging by MRI, pediatric proctology) and therapeutic care. We are therefore developing, with cohorts of more than 400 patients, adapted care pathways and numerous research programs, whether it concerns nutritional treatment in Crohn’s disease and, above all, biological treatments (biotherapy by monoclonal antibodies) .
Short bowel syndrome
- Linked to a congenital malformation (Atresia, laparochisis) Q41 *
- Linked to postnatal ischemic attack (enterocolitis, small bowel volvulus) [No specific code (PCS)]
Digestive neuromuscular diseases (MNMD)
- Chronic intestinal pseudo-obstruction syndrome K560
- Hirschsprung’s disease spread to the small intestine Q431
Congenital enteropathies of the intestinal mucosa development
- Microvillus atrophy (MYO5B, STX3) (PCS)
- Intestinal epithelial dysplasia (Epcam, Spint2) (PCS)
- Syndromic diarrhea (SKIV2L, TTC37) (PCS)
- Neurogenin 3 deficiency (PCS), UNC45A mutation and other mutations
Crohn’s disease K50 *
Ulcerative colitis K51 *
Undifferentiated colitis K52 *
Autoimmune enteropathies (PCS)
Monogenic inflammatory colitis (PCS)
Diseases of digestion / absorption / intestinal transport
- Glucose-galactose malabsorption E743
- Congenital chlorinated diarrhea P783
- Hypo and a-beta lipoproteinemias (PCS)
- Digestive polyps and polyposes D126, 126 + 4, 126 + 5
Chronic pancreatitis
Malformative pancreatitis Q450, Q451, Q453
Hereditary chronic pancreatitis K861
- Pr Frank Ruemmele, Head of department of pediatric gastroenterology and nutrition| IBD and digestive immunopathologies | Head of the reference center
- Dr Cécile Lambe, nutrition and HPN program
- Dr Cécile Talbotec, digestive endoscopy and HPN program
- Dr Bénédicte Pigneur, digestive endoscopy, IBD and pediatric proctology
- Dr Elie Abi Nader, IBD, outpatient gastroenterology, digestive endoscopy
- Dr Elise Payen, nutrition and HPN program, IBD and digestive endoscopy
- Pr assoc. Florence Campeotto, outpatient gastroenterology, IBD, digestive endoscopy, functional digestive exploration
- Dr Myriam Dabbas, nutrition and obesity program
- Dr Florence Lacaille, hepatopediatrician | intestinal and liver transplant program
- Catherine Poisson, nurse coordinator and trainer in pediatric therapeutic education (TPE) for the HPN and home enteral nutrition program
- Amelia Rocha, nurse trainer for the HPN program in the HPN and home enteral nutrition program
- Emilie Foucard, TPE nurse trainer for the IBD and constitutional digestive immunopathologies program
- Djamila Feeza, TPE nurse trainer for the transplant program
- Dorothée Franck-Luquet, social worker
- Aurelia Guillemin, clinical psychologist
- Alice Dubusson, health executive
- Isabelle Martinez, early childhood educator
- Home parental nutrition
- Home enteral nutrition
- Chronic inflammatory bowel disease (IBD) and congenital digestive immune pathologies
- Intestinal and hepato-intestinal and hepatic transplantation
REVE study (AP-HP promoter; Principal investigator Pr Olivier Goulet)
Treatment of short bowel syndrome with recombinant GLP-2 hormone (Revestive® Shire): (clinical trial in progress (partnership with Imagine, AP-HP and Shire)
CD-Hope study : nutritional treatment as a maintenance treatment for Crohn’s disease (multicenter clinical trial in progress, Principal investigator: F. Ruemmele, sponsor: APHP-NEM, partnership with Nestlé Clinical Science)
Horizon2020 project (Funds obtained from the European Commission) – PIBDSetquality : Principal investigator: Pr. Frank Rümmele, with 2 objectives:
- Multicenter clinical trial of therapeutic strategy for Crohn’s disease (ANSM and CPP agreement 11/2016): recruitment of the 1st patient scheduled for 01/2017,
- Inception cohort: assessment of the risks and complications of children / adolescents with IBD
Immunobiota study (Pr Frank Rümmele, coordinating investigator, Hôpital Necker-Enfants Malades, Dr Nadine Cerf-Bensussan, scientific director) Advanced ECR Grant (European Commission) Dr Nadine Cerf-Bensussan, (Institut Imagine, Inserm U1163, Paris)
- Objective: to characterize phenotypically (clinical) and genetically (molecular) children with immune enteropathy / IPDMG (such as autoimmune enteropathies, IPEX, XIAP, IL10 signaling deficiency, etc.)
- Development of a research diagnostic chip for these pathologies
- Participation of 12 French pediatric centers and 1 adult IBD center (protocol in place since 12/2015) and collaboration with the GENIUS working group of ESPGHAN [initiated in 2009 by Frank Rümmele, bringing together patients from 20 European countries and beyond (www.genius-group.org)]
Interuniversity diploma in clinical nutrition and metabolism
Paris-Descartes, Clermont-Ferrand, Grenoble, Lyon, Rouen, Versailles-Saint-Quentin, Brest, Nice + Brussels, Geneva, Lausanne universities
Olivier Goulet: manager at Paris-Descartes
Interuniversity diploma in pediatric gastroenterology-hepatology-nutrition
Paris-Descartes, Aix-Marseille, Angers, Bordeaux, Caen, Clermont-Ferrand, Lille, Lyon, Montpellier, Nancy, Paris VI, Paris VII, Paris XI, Rennes, Toulouse and Tours universities
Thierry Lamireau: head of Bordeaux university
2021
– Cannabinoids Improve Gastrointestinal Symptoms in a Parenteral Nutrition-Dependent Patient With Chronic Intestinal Pseudo-Obstruction.
Boutaina Zemrani, Cécile Lambe, Olivier Goulet
JPEN J Parenter Enteral Nutr, 2021 Feb, PMID: 32181915 DOI: 10.1002/jpen.1821
– The use of biofeedback for children with fecal incontinence secondary to retentive constipation: Experience of a French Pediatric Center.
Elie Abi Nader, Ombeline Roche, Jean-Philippe Jais, Julie Salomon, Olivier Goulet, Florence Campeotto
Clin Res Hepatol Gastroenterol, 2021 May, PMID: 33481704 DOI: 10.1016/j.clinre.2020.09.011
– Metabolic bone disease in children with intestinal failure is not associated with the level of parenteral nutrition dependency.
Elie Abi Nader, Cécile Lambe, Cécile Talbotec, Alexandre Acramel, Bénédicte Pigneur, Olivier Goulet
Clin Nutr, 2021 Apr, PMID: 32977995 DOI: 10.1016/j.clnu.2020.09.014
– Variation of plasma citrulline as a predictive factor for weaning off long-term parenteral nutrition in children with neonatal short bowel syndrome.
Francesco Proli, Andrea Faragalli, Cécile Talbotec, Andrea Bucci, Boutaina Zemrani, Christophe Chardot, Elie Abi Nader, Olivier Goulet, Cécile Lambe
Clin Nutr, 2021 Aug, PMID: 34358840 DOI: 10.1016/j.clnu.2021.07.017
– Corrigendum to: Diagnostic Yield of Next-Generation Sequencing in Very Early-Onset Inflammatory Bowel Diseases: A Multicenter Study.
Fabienne Charbit-Henrion, Marianna Parlato, Sylvain Hanein, Rémi Duclaux-Loras, Jan Nowak, Bernadette Begue, Sabine Rakotobe, Julie Bruneau et al.
J Crohns Colitis, 2021 Mar 5, PMID: 32895718 PMCID: PMC7944498 DOI: 10.1093/ecco-jcc/jjaa164
– Benign Evolution of SARS-Cov2 Infections in Children With Inflammatory Bowel Disease: Results From Two International Databases.
Erica J Brenner, Bénédicte Pigneur, Gili Focht, Xian Zhang, Ryan C Ungaro, Jean-Frederic Colombel, Dan Turner, Michael D Kappelman, Frank M Ruemmele
Clin Gastroenterol Hepatol, 2021 Feb, PMID: 33059040 PMCID: PMC7550063 DOI: 10.1016/j.cgh.2020.10.010
– Inflammatory Bowel Disease in Patients with Congenital Chloride Diarrhoea.
Lorenzo Norsa, Roberto Berni Canani, Remi Duclaux-Loras, Emeline Bequet, Jutta Köglmeier, Richard K Russell, Holm H Uhlig, Simon Travis, Jennifer Hollis, Sibylle Koletzko, Giusi Grimaldi, Giuseppe Castaldo, Astor Rodrigues, Jaques Deflandre, Lukasz Dembinski, Neil Shah, Peter Heinz-Erian, Andreas Janecke, Saara Leskinen, Satu Wedenoja, Ritva Koskela, Alain Lachaux, Kaija-Leena Kolho, Frank M Ruemmele
J Crohns Colitis, 2021 Oct 7, PMID: 33770165 DOI: 10.1093/ecco-jcc/jjab056
– Is sexual harassment and psychological abuse among medical students a fatality? A 2-year study in the Paris Descartes School of Medicine.
Quentin Lisan, Bénédicte Pigneur, Simon Pernot, Cécile Flahault, Frédéric Lenne, Gérard Friedlander, Cécile Badoual, Brigitte Ranque, Cédric Lemogne
Med Teach, 2021 Sep, PMID: 33882785 DOI: 10.1080/0142159X.2021.1910225
2020
– Designing clinical trials in paediatric inflammatory bowel diseases: a PIBDnet commentary.
Dan Turner, Anne M Griffiths, David Wilson, Diane R Mould, Robert N Baldassano, Richard K Russell, Marla Dubinsky, Melvin B Heyman, Lissy de Ridder, Jeffrey Hyams, Javier Martin de Carpi, Laurie Conklin, William A Faubion, Sibylle Koletzko, Athos Bousvaros, Frank M Ruemmele
Gut, 2020 Jan, PMID: 30979718 DOI: 10.1136/gutjnl-2018-317987
– Neurological Adverse Effects Associated with anti-TNF Alpha Antibodies in Pediatric Inflammatory Bowel Diseases.
Valérie Bertrand, Nathalie Massy, Bénédicte Pigneur, Stéphanie Coopman, Geneviève Durrieu, Louise Gaboriau, Vincent Langlois, Corinne Gower-Rousseau, Jean-Pierre Hugot, Frank M Ruemmele, GETAID (Groupe d’Etude thérapeutique des Affections Inflammatoires du Tube Digestif) Pdiatrique
J Pediatr Gastroenterol Nutr, 2020 Jun, PMID: 32443044 DOI: 10.1097/MPG.0000000000002654
– Lipid Emulsion Use in Pediatric Patients Requiring Long-Term Parenteral Nutrition.
Olivier J Goulet, Wei Cai, Jeong-Meen Seo
JPEN J Parenter Enteral Nutr, 2020 Feb, PMID: 32049395 DOI: 10.1002/jpen.1762
– Beyond 10 years, with or without an intestinal graft: Present and future?
Sophie Courbage, Danielle Canioni, Cécile Talbotec, Cécile Lambe, Christophe Chardot, Marion Rabant, Louise Galmiche, Olivier Corcos, Olivier Goulet, Francisca Joly, Florence Lacaille
Am J Transplant, 2020 Oct, PMID: 32277553 DOI: 10.1111/ajt.15899
– Neurological Adverse Effects Associated With Anti-tumor Necrosis Factor Alpha Antibodies in Pediatric Inflammatory Bowel Diseases.
Valérie Bertrand, Nathalie Massy, Bénédicte Pigneur, Stéphanie Coopman, Geneviève Durrieu, Louise Gaboriau, Vincent Langlois, Corinne Gower-Rousseau, Jean-Pierre Hugot, Frank M Ruemmele, GETAID (Groupe d’Etude thérapeutique des Affections Inflammatoires du Tube Digestif) Pdiatrique
J Pediatr Gastroenterol Nutr, 2020 Jun, PMID: 32443044 DOI: 10.1097/MPG.0000000000002654
– The Medical Management of Paediatric Crohn »s Disease: an ECCO-ESPGHAN Guideline Update.
Patrick F van Rheenen, Marina Aloi, Amit Assa, Jiri Bronsky, Johanna C Escher, Ulrika L Fagerberg, Marco Gasparetto, Konstantinos Gerasimidis, Anne Griffiths, Paul Henderson, Sibylle Koletzko, Kaija-Leena Kolho, Arie Levine, Johan van Limbergen, Francisco Javier Martin de Carpi, Víctor Manuel Navas-López, Salvatore Oliva, Lissy de Ridder, Richard K Russell, Dror Shouval, Antonino Spinelli, Dan Turner, David Wilson, Eytan Wine, Frank M Ruemmele
J Crohns Colitis, 2020 Oct 7, PMID: 33026087 DOI: 10.1093/ecco-jcc/jjaa161
– Clostridium difficile: A Frequent Infection in Children After Intestinal Transplantation.
Rémi Duclaux-Loras, Julien Berthiller, Agnès Ferroni, Christophe Chardot, Olivier Goulet, Florence Lacaille, Lorenzo Norsa
Transplantation, 2020 Jan, PMID: 31205257 DOI: 10.1097/TP.0000000000002795
2019
- Short Bowel Syndrome as the Leading Cause of Intestinal Failure in Early Life: Some Insights into the Management.
Goulet, O ; Abi Nader, E ; Pigneur, B ; Lambe, C
Pediatr Gastroenterol Hepatol Nutr, 2019 Jul, PMID: 31338307 PMCID: PMC6629594 DOI: 10.5223/pghn.2019.22.4.303 - Paediatricians play a key role in preventing early harmful events that could permanently influence the development of the gut microbiota in childhood.
Goulet, O ; Hojsak, I ; Kolacek, S ; Pop, TL ; Cokugras, FC ; Zuccotti, G & al
Acta Paediatr, 2019 Nov, PMID: 31197890 PMCID: PMC6852013 DOI: 10.1111/apa.14900 - Colon importance in short bowel syndrome.
Lambe, C ; Goulet, O ; Norsa, L
Aging (Albany NY), 2019 Nov 15, PMID: 31733102 PMCID: PMC6914415 DOI: 10.18632/aging.102447 - Mucosal Healing and Bacterial Composition in Response to Enteral Nutrition Vs Steroid-based Induction Therapy-A Randomised Prospective Clinical Trial in Children With Crohn »s Disease.
Pigneur, B ; Lepage, P ; Mondot, S ; Schmitz, J ; Goulet, O ; Doré, J & al
J Crohns Colitis, 2019 Jul 25, PMID: 30541015 DOI: 10.1093/ecco-jcc/jjy207 - Nutritional interventions for the treatment of IBD: current evidence and controversies.
Pigneur, B ; Ruemmele, FM
Therap Adv Gastroenterol, 2019 Nov 25, PMID: 31803252 PMCID: PMC6878599 DOI: 10.1177/1756284819890534 - Safety of anti-TNF biologics in paediatric inflammatory bowel disease.
Ruemmele, FM
Lancet Gastroenterol Hepatol, 2019 Nov, PMID: 31494098 DOI: 10.1016/S2468-1253(19)30292-4 - The colon as an energy salvage organ for children with short bowel syndrome.
Norsa, L ; Lambe, C ; Abi Abboud, S ; Barbot-Trystram, L ; Ferrari, A ; Talbotec, C & al
Am J Clin Nutr, 2019 Apr 1, PMID: 30924493 DOI: 10.1093/ajcn/nqy367 - Long term outcomes of intestinal rehabilitation in children with neonatal very short bowel syndrome: Parenteral nutrition or intestinal transplantation.
Norsa, L ; Artru, S ; Lambe, C ; Talbotec, C ; Pigneur, B ; Ruemmele, F & al
Clin Nutr, 2019 Apr, PMID: 29478887 DOI: 10.1016/j.clnu.2018.02.004 - Short bowel syndrome in children and adults: from rehabilitation to transplantation.
Lauro, A ; Lacaille, F
Expert Rev Gastroenterol Hepatol, 2019 Jan, PMID: 30791840 DOI: 10.1080/17474124.2019.1541736 - Efficacy of Ruxolitinib Therapy in a Patient With Severe Enterocolitis Associated With a STAT3 Gain-of-Function Mutation.
Parlato, M ; Charbit-Henrion, F ; Abi Nader, E ; Begue, B ; Guegan, N ; Bruneau, J & al
Gastroenterology, 2019 Mar, PMID: 30557559 PMCID: PMC6433619 DOI: 10.1053/j.gastro.2018.11.065 - Reply letter to the comment of Christmann V on 2018 ESPGHAN/ESPEN/ESPR/CSPEN guidelines on pediatric parenteral nutrition: Calcium, phosphorus and magnesium.
Mihatsch, W ; Fewtrell, M ; Goulet, O ; Molgaard, C ; Picaud, JC ; Senterre, T
Clin Nutr, 2019 Oct, PMID: 31421871 DOI: 10.1016/j.clnu.2019.07.006 - Intestinal dysbiosis in inflammatory bowel disease associated with primary immunodeficiency.
Sokol, H ; Mahlaoui, N ; Aguilar, C ; Bach, P ; Join-Lambert, O ; Garraffo, A & al
J Allergy Clin Immunol, 2019 Feb, PMID: 30312711 DOI: 10.1016/j.jaci.2018.09.021 - Algorithms to Define Abnormal Growth in Children: External Validation and Head-To-Head Comparison.
Scherdel, P ; Matczak, S ; Léger, J ; Martinez-Vinson, C ; Goulet, O ; Brauner, R & al
J Clin Endocrinol Metab, 2019 Feb 1, PMID: 30137417 DOI: 10.1210/jc.2018-00723 - More research is needed on the use of probiotics for critically ill patients.
Hojsak, I ; Fabiano, V ; Pop, TL ; Goulet, O ; Zuccotti, GV ; Çokuğraş, FC & al
Acta Paediatr, 2019 Jan, PMID: 30129274 DOI: 10.1111/apa.14547 - Pediatric intestinal transplantation: Analysis of the intestinal transplant registry.
Raghu, VK ; Beaumont, JL ; Everly, MJ ; Venick, RS ; Lacaille, F ; Mazariegos, GV
Pediatr Transplant, 2019 Dec, PMID: 31531934 PMCID: PMC6879795 DOI: 10.1111/petr.13580 - Experience of Using a Semielemental Formula for Home Enteral Nutrition in Children: A Multicenter Cross-sectional Study.
Leonard, M ; Caldari, D ; Mas, E ; Lambe, C ; Comte, A ; Ley, D & al
J Pediatr Gastroenterol Nutr, 2019 Apr, PMID: 30896609 DOI: 10.1097/MPG.0000000000002236 - Diagnostic and Therapeutic Approach in Paediatric Inflammatory Bowel Diseases: Results from a Clinical Practice Survey.
Bronsky, J ; de Ridder, L ; Ruemmele, FM ; Griffiths, A ; Buderus, S ; Hradsky, O & al
J Pediatr Gastroenterol Nutr, 2019 May, PMID: 30664566 DOI: 10.1097/MPG.0000000000002233 - The effects of concomitant immunomodulators on the pharmacokinetics, efficacy and safety of adalimumab in paediatric patients with Crohn »s disease: a post hoc analysis.
Hyams, JS ; Dubinsky, M ; Rosh, J ; Ruemmele, FM ; Eichner, SF ; Maa, JF & al
Aliment Pharmacol Ther, 2019 Jan, PMID: 30506693 DOI: 10.1111/apt.15054
2018
- Efficacy of Adalimumab for Treatment of Perianal Fistula in Children with Moderately to Severely Active Crohn’s Disease: Results from IMAgINE 1 and IMAgINE 2.
Ruemmele FM, Rosh J, Faubion WA, Dubinsky MC, Turner D, Lazar A, Eichner S, Maa JF, Alperovich G, Robinson AM, Hyams JS.
J Crohns Colitis, 2018 Nov 9, PMID: 29939254 PMCID: PMC6225974 DOI: 10.1093/ecco-jcc/jjy087 - Differences in epidemiological features between ulcerative colitis and Crohn’s disease: The early life-programmed versus late dysbiosis hypothesis.
Beaugerie L, Langholz E, Nyboe-Andersen N, Pigneur B, Sokol H; ECCO Epicom.
Med Hypotheses, 2018 Jun, PMID: 29685190 DOI: 10.1016/j.mehy.2018.03.009 - Diagnostic Yield of Next-Generation Sequencing in Very Early-Onset Inflammatory Bowel Diseases: A Multicenter Study.
Charbit-Henrion F, Parlato M, Hanein S, et al.
J Crohns Colitis, 2018 Aug 29, PMID: 29788237 PMCID: PMC6113703 DOI: 10.1093/ecco-jcc/jjy068
2017
- Twenty-eight years of intestinal transplantation in Paris: experience of the oldest European center.
Lacaille F, Irtan S, Dupic L, Talbotec C, Lesage F, Colomb V, Salvi N, Moulin F, Sauvat F, Aigrain Y, Revillon Y, Goulet O, Chardot C.
Transpl Int, 2017 Feb, PMID: 27889929 DOI: 10.1111/tri.12894
2016
- Outcome of home parenteral nutrition in 251 children over a 14-y period: report of a single center.
Abi Nader E, Lambe C, Talbotec C, Pigneur B, Lacaille F, Garnier-Lengliné H, Petit LM, Poisson C, Rocha A, Corriol O, Aigrain Y, Chardot C, Ruemmele FM, Colomb-Jung V, Goulet O.
Am J Clin Nutr, 2016 May, PMID: 27030532 DOI: 10.3945/ajcn.115.121756
2015
- Congenital diarrhoeal disorders: advances in this evolving web of inherited enteropathies.
Canani RB, Castaldo G, Bacchetta R, Martín MG, Goulet O.
Nat Rev Gastroenterol Hepatol, 2015 May, PMID: 25782092 PMCID: PMC7599016 DOI: 10.1038/nrgastro.2015.44
Contact information
Necker-Enfants malades university hospital
> Department of pediatric gastroenterology and nutrition
149 rue de Sèvres
75743 PARIS Cedex 15
In Necker, the reference center for rare digestive diseases (MaRDI) is …
* data valid for 2022