Clefts and facial malformations (MAFACE)

French national reference center for clefts and facial malformations (MAFACE)

The reference center for clefts and facial malformations (MAFACE) is integrated into the department of maxillofacial surgery and plastic surgery directed by professor arnaud Picard at Necker-Enfants malades. All of the department’s practitioners and caregivers are involved to varying degrees in the care of clefts and facial malformations, depending on their status, field of competence and expertise.

This reference center is affiliated to the TETECOU rare diseases healthcare network and to the Craniofacial and ENT (ERN CRANIO) European reference network.


Arnaud Picard - responsable médical du centre de référence des fentes et malformations faciales (MAFACE)

Center manager and national coordinator
Arnaud Picard

Eva Galliani - chirurgien référent du centre de référence des fentes et malformations faciales (MAFACE)
Referent surgeon
Dr Eva Galliani


Contact us

Phone. +33 1 44 49 43 16

> Send an email

It is a nurse who answers and manages the appointment of a new consultant. She collects all the information and the medical file in order to adapt the initial appointment as well as possible.

A specific form is provided for pregnant women and newborns.

In case of emergency

Multidisciplinary care at the MAFACE reference center is provided from the antenatal period (antenatal diagnosis of facial malformations), then from birth to the end of growth (20/21 years). Therapeutic strategies are intertwined across all MAFACE disciplines. Everything is organized to limit the impact on the child’s personal, family, school and sports life. Surgery, often iterative and heavy throughout growth, is the key to treatment.

The medical team at the rare diseases reference center (CRMR) includes maxillofacial surgeons, plastic surgeons, orthodontists, pedodontists, speech therapists and a psychologist. The paramedical team includes health care managers, nurses (including childcare nurses), health care aides (including childcare assistants), prosthetists and a medical photographer.

Some consultations are done with a single practitioner, others with several specialists (so-called multidisciplinary consultations). Each stage of multidisciplinary treatment should improve outcomes. Surgery is inseparable from orthodontics, pediatric dentistry, speech therapy and psychological care. The goal is rehabilitation as close to normal as possible.

Part of the treatment is obligatorily provided on the Necker site within the CRMR: sometimes very heavy surgical procedures, complex or innovative orthodontic treatments, specific pedodontic treatments or those that must be performed under anesthesia and/or during surgery, specific speech therapy assessments or psychological assessments. But everything that can be carried out near the home is privileged: orthodontic treatments including pre-surgical treatments, speech therapy re-education, pedodontic care, psychological follow-up, ENT follow-up and treatments, pediatric follow-up in connection with the center, psychiatric and/or psychological follow-up. A social worker is available to help all families with social or administrative difficulties.

A document with all CRMR phone numbers and email addresses, including emergency numbers, is given to each child and their parents at each consultation.

The CRMR collaborates closely for the multidisciplinary care of pathologies with the 4 other reference centers of the TETECOU sector: CRMR CRANIOST, CRMR MALO, CRMR ORARES and CRMR SPRATON.

Facial clefts

  • median clefts: labio-mandibular clefts, fronto-nasal clefts ;
  • cleft lip and palate: cleft lip and labial-alveolar clefts (25%), cleft palate (25-30%), cleft lip and palate (45-50%). These are the most frequent among facial clefts ;
  • orbital-facial clefts, oblique facial clefts
  • lateral clefts : commissural clefts, full lateral clefts
  • associated syndromes: 30% of clefts are associated with syndromes: Pierre Robin syndrome (17q24, SOX9 gene), van der Woude syndrome (IRF6 gene, locus 1q32-q41), EEC syndrome (TP63 gene, locus 3q27 or 7q21), oto-palato-digital syndrome; faciogenitopopliteal syndrome, OFD syndromes(oral-facial-digital) , BOF syndrome (Branchio-oculo-facial), arthrogryposis …

Oto-mandibular dysplasias

  • hemifacial microsomias, unilateral or bilateral craniofacial microsomias ;
  • Associated syndromes: Goldenhar syndrome, Nager syndrome, Miller syndrome, Treacher-Collins or Franceschetti syndrome, Hallermann Streiff syndrome, Guoin Almeida type mandibulo-facial dysostosis.

Very rare facial malformations

  • proboscis ;
  • nose duplication ;
  • maxillo-nasal dysplasia, Binder syndrome;
  • teratomas;
  • epignathus;
  • congenital giant epulis.

Craniofacial synostosis

  • for maxillofacial care, in collaboration with the CRMR CRANIOST.

Congenital cysts and fistulas of the face

Congenital vascular malformations and tumors (angiomas)

  • capillar-venous, venous, arteriovenous, lymphatic (macro- and microcystic) malformations ;
  • RICH, NICH, PICH tumors, giant hemangiomas ;
  • Associated syndromes: CLOVES syndrome, Sturges-Weber syndrome, Klippel-Treanunay syndrome, Parker-Weber syndrome, Cobb syndrome, Proteus syndrome, CAVMS, Kasabach-Merritt syndrome, PHACE syndrome.

Congenital microglossia

  • Associated hypoglossal growth syndromes : Hypoglossia-Hypodactyly syndrome, Hanhart syndrome, Silver Russell syndrome.

Congenital macroglossia, hemi-facial hypertrophy

  • Associated hypergrowth syndromes : Wiedemann-Beckwith syndrome, Golabi syndrome, Cloves syndrome.

Tissue dysplasias

  • giant congenital pigmentary naevus ;
  • aplasia cutis ;
  • hamartomas ;
  • linear localized sclerodermas ; Parry-Romberg syndrome.

Paralytic malformations of the face, Moebius syndrome

Congenital velopharyngeal incompetence

  • Associated syndromes: Kabuki syndrome, 22q11 deletion

The department also takes care of the following pathologies, apart from those of the reference center :

At the level of the face, the oral cavity and the scalp :

  • Bone and soft tissue trauma – Dog bites ;
  • benign and malignant bone and soft tissue tumors ;
  • infections.

At the level of the face and the whole body envelope :

  • vascular abnormalities ;
  • tissue dysplasias and giant naevus of the body;
  • after-effects of burns;
  • scars;
  • facial plastic surgery.

Body plastic surgery.

En savoir +

Centre de référence des fentes et malformations faciales (MAFACE)

Pr Arnaud Picard
maxillo-facial surgeon,
responsible for the reference center,
national coordinator of the MAFACE network

Dr Eva Galliani
maxillo-facial surgeon,
referring surgeon of the reference center,
assistant to the coordinator,
BAMARA referent

Pr Natacha Kadlub
maxillo-facial surgeon,
rare tumors and bone diseases referent (MOC)

Dr Hossein Khonsari Craniost

Dr Hossein Roman Khonsari
maxillo-facial surgeon,
CRANIOST referent

Dr Anne Morice
maxillo-facial surgeon

Cecilia Neiva-Vaz magec

Dr Cécilia Neiva-Vaz
maxillo-facial surgeon,
microsurgery and reconstruction referent

Véronique Soupre magec

Dr Véronique Soupre
maxillo-facial surgeon,
referent for antenatal diagnosis (CPDPN), and
for vascular abnormalities (AVANCE)

Marie Paule Vazquez magec

Pr Marie-Paule Vazquez
maxillo-facial surgeon
plastic surgeon,
medical-surgical referent of the TETECOU sector

Jacques Buis magec

Dr Jacques Buis
plastic surgeon

Patrick Diner Magec

Dr Patrick Diner
plastic surgeon,
surgical bone distraction referent

Dr Gérald Franchi
plastic surgeon,
orbito-palpebral malformations referent

Dr Benoit Michel magec

Dr Benoît Michel
maxillo-facial surgeon

Marc Mitrofanoff magec

Dr Marc Mitrofanoff
plastic surgeon

Bernard Sergent magec

Dr Bernard Sergent
plastic surgeon,
Moebius syndrome referent

Frédéric Zazurca magec

Dr Frédéric Zazurca
plastic surgeon

Catherine Tomat Magec

Dr Catherine Tomat
stomatologist and orthodontist,
bone distraction orthodontic referent

photo-identite-femme magec2

Dr Bothild Kverneland
pediatric odontologist

Dr Ioana Pavlov Magec

Dr Ioana Pavlov
pediatric odontologist

Dr Amélie Reibel-Domergue Magec

Dr Amélie Reibel-Domergue
pediatric odontologist

Dr Hien Tran
pediatric odontologist

photo-identite-femme magec2

Dr Sophie Eché

dr-Le-mai-khanh Magec

Dr Mai Khanh Lê-Dacheux


Dr Aurélie Majourau-Bourriez

Fatiha Nassef Magec

Dr Fatiha Nassef-Guérard

Dr Khanh Nham

Brigitte Vi-Fane Magec

Dr Brigitte Vi-Fane
MAFACE/ORARES clefts orthodontist referent

Dr Bachar Houssamo

Christine Baton Magec

Dr Christine Baton
scars referent

Virgine Fayard Magec

Dr Virginie Fayard
laser referent

Alexandra Bucur-Girard
speech therapist

Cecile Chapuis Magec

Cécile Chapuis
speech therapist,
MAFACE reference center referent,
training referent in the MAFACE network

Valerie Charpillet Magec

Valérie Charpillet
speech therapist,
Moebius syndrome referent

Estelle Sanquer
speech therapist

Pascal Gavelle magec

Pascale Gavelle

Beatrice Langellier Magec

Béatrice Langellier-Bellevue
reference center social worker

Labortoire de recherche

Bone distraction and bone surgery

  • VIVODOGMA project: development of a craniofacial osteogenic distractor with magnetic activation (collaboration Institut Polytechnique de Paris/University of Paris/APHP)
  • PROTODISMA project: development of a prototype of a magnetically activated inter-maxillary circuit breaker (collaboration Institut Polytechnique de Paris/University of Paris/APHP)
  • Development of customized surgical bone distractors
  • Pre-operative 3D planning and 3D printing of models and medical devices in the hospital environment
  • Development of a high-fidelity model of mandibular bone impression (collaboration Institut Polytechnique de Paris/University of Paris)
  • Biomechanical study of the mandibular periosteum (collaboration Institut Polytechnique de Paris/University of Paris)
  • Biomechanical study of decellularized bone (collaboration Institut Polytechnique de Paris/ University of Paris/ Catholic university of Louvain)

Facial clefts

  • Cohort study of patients with unilateral or bilateral cleft lip and palate : Primary cheilorhinoplasty/veloplasty studies : results at 4 years.
  • Cohort study of patients with uni- or bilateral commissural clefts
  • Evaluation of the use of biomaterials in alveolar grafts for cleft lip and palate
  • Oral hygiene and Kolibree connected toothbrush prior to alveolar bone grafting in children with cleft lip and/or palate
  • Evaluation of the effects of the interactive story box LUNII on pre-operative anxiety and on the post-operative period of children with cleft lip and/or palate admitted for alveolar bone grafting: a pilot study (LUNII) >> clinicaltrials

Constitutional bone diseases (collaboration with the MOC reference center)

  • Clinical study, maxillofacial phenotype of patients with achondroplasia

Craniofacial malformations (collaboration with the CRANIOST reference center)

  • Craniofacial phenotype of intentional skull deformities
  • Mandibular morphology in craniofacial synostosis
  • Black-Bone MRI data segmentation
  • Oral opening after craniofacial osteotomies (monobloc and Le Fort III osteotomies)
  • Recognition of craniofacial syndromes by artificial intelligence based on 2D and 3D photographs
  • Optimization of bone remodeling in fronto-orbital advancement

Rare oncology

  • EuroEwing national cohort study, Care of Ewing’s sarcoma of the head and neck (IGR collaboration)
  • Cohort clinical studies rare head and neck tumors (MNTI, desmoide, TKO…)
  • Molecular and cellular study of cherubism (collaboration with the MOC reference center)

Hamartomas/tissue dysplasias

  • Study of interactions between melanocytic cells and keratinocytes
  • Morphology of scars in iterative naevus excisions

Studies of incisions and skin plasties for the separation of ischiopagus twins (siamese), (collaboration with the visceral surgery and orthopedic surgery departments of Necker)

Inter-university diploma in pediatric plastic surgery
University of Montpellier – University of Toulouse

Inter-university diploma in fetal medicine
Universities of Paris Pierre and Marie Curie and Kremlin Bicêtre

Inter-university diploma in fetal medicine
Universities of Bordeaux, Lille, Montpellier, Paris Descartes, Rennes and Tour

University diploma in dermato-venereology of the oral mucosa
University of Paris Descartes

Inter-university diploma in surgical anatomy of the head and neck
University Paris-Descartes – University of Paris-Diderot

Inter-university diploma in medicine and neonatal resuscitation (Inter-regional east)
Universities of Dijon, Lyon, Marseille, Montpellier, Nancy, Reims, Strasbourg

Inter-university diploma in medicine and neonatal resuscitation (Inter-regional west)
Universities of Amiens, Bordeaux, Brest, Caen, Lille, Nantes, Rennes, Rouen, Tours

University diploma in clef lip and palate : multidisciplinary therapeutic approaches
University of Strasbourg 

University diploma in surgical planning and personalized medicine: from image processing to risk management
University of Paris Descartes

University diploma in artificial intelligence in health
University of Paris

Inter-university diploma in medicine and neonatal resuscitation (Inter-regional Paris Ile-de-France)
Universities of Paris Descartes, Pierre et Marie Curie, Diderot et Kremlin Bicêtre

The publications detailed here are from

  • the MAFACE reference center and the work of all its members
  • collaboration with research laboratories
  • collaboration with the 4 other reference centers of the TETECOU sector: CRANIOST, MALO, SPRATON and ORARES
  • collaborations with the dermatology, ophthalmology, non-invasive ventilation and sleep of children, visceral surgery, orthopedic surgery, anatomopathology, neurophysiology and genetics departments of Necker-Enfants malades.


– Evaluation of prenatal breastfeeding workshop to inform and support mother with antenatal diagnosis of cleft lip/palate
Marie-Camille CosteMarine HubyCécilia Neiva-VazVéronique SoupreArnaud PicardNatacha Kadlub
Journal of Stomatology, Oral and Maxillofacial Surgery , 2022 June,


The use of three-dimensional reconstructions of CT scans to evaluate anomalies of hyoid bone in Pierre Robin sequence: A retrospective study.
A Giudice, K Belhous, S Barone, V Soupre, A Morice, M-P Vazquez, N Boddeart, V Abadie, A Picard
J Stomatol Oral Maxillofac Surg, 2020 Sep, PMID: 31499229 DOI: 10.1016/j.jormas.2019.08.014

International Society of Craniofacial Surgery, XVIIIth biennal meeting in Paris: A report.
R H Khonsari, G Paternoster
J Stomatol Oral Maxillofac Surg, 2020 Feb, PMID: 31672682 DOI: 10.1016/j.jormas.2019.10.009

Extraocular muscle positions in anterior plagiocephaly: V-pattern strabismus explained using geometric mophometrics.
Romain Touzé, Yann Heuzé, Matthieu P Robert, Dominique Brémond-Gignac, Charles-Joris Roux, Syril James, Giovanna Paternoster, Eric Arnaud, Roman Hossein Khonsari
Br J Ophthalmol, 2020 Aug, PMID: 31694836 DOI: 10.1136/bjophthalmol-2019-314989

Early mandibular morphological differences in patients with FGFR2 and FGFR3-related syndromic craniosynostoses: A 3D comparative study.
A Morice, R Cornette, A Giudice, C Collet, G Paternoster, É Arnaud, E Galliani, A Picard, L Legeai-Mallet, R H Khonsari
Bone, 2020 Dec, PMID: 32822871 DOI: 10.1016/j.bone.2020.115600

Cherubism as a systemic skeletal disease: evidence from an aggressive case.
Anne Morice, Aline Joly, Manon Ricquebourg, Gérard Maruani, Emmanuel Durand, Louise Galmiche, Jeanne Amiel, Yoann Vial, Hélène Cavé, Kahina Belhous, Marie Piketty, Martine Cohen-Solal, Ariane Berdal, Corinne Collet, Arnaud Picard, Amelie E. Coudert & Natacha Kadlub
BMC Musculoskelet Disord, 2020 Aug 21, PMID: 32825821 PMCID: PMC7441549 DOI: 10.1186/s12891-020-03580-z

The histopathology of congenital hemangioma and its clinical correlations: a long-term follow-up study of 55 cases.
El Zein S, Boccara O, Soupre V, Vieira AF, Bodemer C, Coulomb A, Wassef M, Fraitag S.
Histopathology (2020)

Modeling of the human mandibular periosteum material properties and comparison with the calvarial
Kadlub N, Debelmas A, Dallard J, Picard A, Boisson J.
Biomechanisms and Modeling in Mechanobioly, 19(2):461-470 (2020)

Orofacial motor dysfunction in Moebius syndrome.
Renault F, Flores-Guevara R, Baudon JJ, Sergent B, Charpillet V, Denoyelle F, Thierry B, Amiel J, Gitiaux C, Vazquez MP.
Developmental Medicine & Child Neurology 62(4):521-527 (2020)

Maxillary shape at the end of puberty in operated unilateral cleft lip and palate: A geometric morphometric assessment using computer tomography.
Segna E, Khonsari RH, Meazzini MC, Battista VMA, Picard A, Autelitano L.
Journal of Stomatology, Oral and Maxillofacial Surgery (1):9-13 (2020)

Sleep-disordered breathing in children with pycnodysostosis.
Khirani S, Amaddeo A, Baujat G, Michot C, Couloigner V, Pinto G, Arnaud E, Picard A, Cormier-Daire V, Fauroux B.
American Journal of Medical Genetics-Part A 182(1):122-129 (2020)

Reproducibility assessment of Delaire cephalometric analysis using reconstructions from computed tomography.
Debelmas A, Ketoff S, Lanciaux S, Corre P, Friess M, Khonsari RH.
Journal of Stomatology, Oral and Maxillofacial Surgery 121(1):35-39 (2020)

The influence of fronto-facial monobloc advancement on obstructive sleep apnea: An assessment of 109 syndromic craniosynostoses cases.
Khonsari RH, Haber S, Paternoster G, Fauroux B, Morisseau-Durand MP, Cormier-Daire V, Legeai-Mallet L, James S, Hennocq Q, Arnaud E.
J Craniomaxillofac (2020)

Excessive ossification of the bandeau in Crouzon and Apert syndromes.
Bouaoud J, Hennocq Q, Paternoster G, James S, Arnaud E, Khonsari RH.
J Craniomaxillofac Surg (2020)

Improvement of Periorbital Appearance in Apert Syndrome After Subcranial Le Fort III With Bipartition and Distraction.
Chetty V, Haber SE, Khonsari RH, Arnaud E.
J Craniofac Surg (2020)

A swollen cheek.
Schlund M, Khonsari RH, Leverd C, Catteau B, Ferri J, Touzet-Roumazeille S.
J Stomatol Oral Maxillofac Surg(2020)

Early presentation in ameloblastic fibroma.
Cieliszka C, Galmiche-Rolland L, Khonsari RH.
J Stomatol Oral Maxillofac Surg;121(1):95-97 (2020)


The use of three-dimensional reconstructions of CT scans to evaluate anomalies of hyoid bone in Pierre Robin sequence: A retrospective study.
Giudice A, Belhous K, Barone S, Soupre V, Morice A, Vazquez MP, Boddeart N, Abadie V, Picard A.
Journal of Stomatology, Oral and Maxillofacial Surgery. S2468-7855(19)30213-7 (2019)

Does surgery of lymphatic malformations lead to an increase in superficial lymphangiectasia? A retrospective study of 43 patients.
Schreiber A, Soupre V, Kadlub N, Galliani E, Picard A, Chrétien-Marquet B, Pannier S, Guéro S, Khen-Dunlop N, Hadj-Rabia S, Delanoe P, Bodemer C, Boccara O.
British Journal of Dermatology. 181(6):1324-1325 (2019)

Les rhinoseptoplasties secondaires des fentes labiopalatines.
Picard A, Zazurca F, Franchi G, Kadlub N, Galliani E, Neiva-Vaz C, Soupre V, Mitrofanoff M, Khonsari RH, Diner PA, Vazquez MP.
Annales de Chirurgie Plastique Esthétique. 64(5-6):432-439 (2019)

Pediatric Nasal Reconstruction by Washio Procedure
O’Rourke SCM, Neiva C, Galliani E, Kadlub N, Picard A, Morice A.
Facial Plastic Surgery. 35(3):286-293 (2019)

Gnathodiaphyseal dysplasia with a novel R597I mutation of ANO5: Mandibular reconstruction strategies.
Marechal G, Schouman T, Mauprivez C, Benassarou M, Chaine A, Diner PA, Zazurca F, Soupre V, Michot C, Baujat G, Khonsari RH.
Journal of Stomatology, Oral and Maxillofacial Surgery 120(5):428-431(2019)

Oral health related quality of life of children and adolescents affected by rare orofacial diseases: a questionnaire-based cohort study.
Friedlander L, Berdal A, Boizeau P, Licht BA, Manière MC, Picard A, Azzis O, Vazquez MP, Alberti C, Molla MD.
Orphanet Journal of Rare Diseases. 14(1):124 (2019)

Extraocular muscle positions in anterior plagiocephaly: V-pattern strabismus explained using geometric mophometrics.
Touzé R, Heuzé Y, Robert MP, Brémond-Gignac D, Roux CJ, James S, Paternoster G, Arnaud E, Khonsari RH.
Br J Ophthalmol (2019)

Defining Critical Ages for Orbital Shape Changes after Frontofacial Advancement in Crouzon Syndrome.
Khonsari RH, Hennocq Q, Nysjö J, Sandy R, Haber S, James S, Britto JA, Paternoster G, Arnaud É.
Plast Reconstr Surg;144(5):841e-852e (2019)

Implementation of a digital chain for the design and manufacture of implant-based surgical guides in a hospital setting.
Pajot T, Benichou L, Moreau E, Tallon V, Meningaud JP, Khonsari RH, Ketoff S.
J Stomatol Oral Maxillofac Surg (2019)

Local Inhibition of MEK/Akt Prevents Cellular Growth in Human Congenital Melanocytic Nevi.
Rouillé T, Aractingi S, Kadlub N, Fraitag S, How-Kit A, Daunay A, Hivelin M, Moguelet P, Picard A, Fontaine RH, Guégan S.
Journal of Investigative Dermatology. 139(9):2004-2015.e13 (2019)

Craniofacial bone atrophy in Parry Romberg syndrome demonstrated using a Bayesian hierarchical model.
Hennocq Q, Facchini A, Kverneland B, Bodemer C, Picard A, Khonsari RH.
Journal of Cranio-Maxillofacial Surgery. 47(6):909-914 (2019)

Maxillary shape after primary cleft closure and before alveolar bone graft in two different management protocols: A comparative morphometric study.
Girinon F, Ketoff S, Hennocq Q, Kogane N, Ullman N, Kadlub N, Galliani E,Neiva-Vaz C, Vazquez MP, Picard A, Khonsari RH.
Journal of Stomatology, Oral and Maxillofacial Surgery 120(5):406-409 (2019)

Mandibular symphyseal distraction osteogenesis: 20 years of experience treating transverse deficiencies with an internal hybrid device
Rougier G, Diner PA, Rachwalski M, Galliani E, Tomat C, Picard A, Kadlub N.
Journal of Cranio-Maxillofacial Surgery. 47(4):586-591 (2019)

Contribution of a better maxillofacial phenotype in Silver-Russell syndrome to define a better orthodontics and surgical management.
Vo Quang S, Galliani E, Eche S, Tomat C, Fauroux B, Picard A, Kadlub N.
Journal of Stomatology, Oral and Maxillofacial Surgery 120. 120(2):110-115 (2019)

Sleep disordered breathing in Silver-Russell syndrome patients: a new outcome.
Giabicani É, Boulé M, Aubertin G, Galliani E, Brioude F, Dubern B, Netchine I.
Sleep Medicine 64:23-29 (2019)

[Development and growth of the vault of the skull].
Catala M, Khonsari RH, Paternoster G, Arnaud É.
Neurochirurgie (2019)

Deep learning in medical image analysis: A third eye for doctors.
Fourcade A, Khonsari RH.
J Stomatol Oral Maxillofac Surg; 120(4):279-288 (2019)

– Management of Gorham Stout disease with skull-base defects: Case series of six children and literature review.
Simon F, Luscan R, Khonsari RH, Toubiana J, Belhous K, James S, Blauwblomme T, Zerah M, Denoyelle F, Donadieu J, Couloigner V.
Int J Pediatr Otorhinolaryngol;124:152-156 (2019)

Current Approaches in the Development of Molecular and Pharmacological Therapies in Craniosynostosis Utilizing Animal Models.
Rachwalski M, Khonsari RH, Paternoster G.
Mol Syndromol 10(1-2):115-123 (2019)

Diagnostic criteria in Pai syndrome: results of a case series and a literature review.
Morice A, Galliani E, Amiel J, Rachwalski M, Neiva C, Thauvin-Robinet C, Vazquez MP, Picard A, Kadlub N.
International Journal of Oral and Maxillofacial Surgery 48(3):283-290 (2019)

Connected toothbrush, augmented reality and oral hygiene in children with cleft lip and palate.
Séblain D, Capitaine AG, Khonsari RH.
Journal of Stomatology, Oral and Maxillofacial Surgery 120(1):83-85 (2019)

Efficacy and Tolerance of Sirolimus (Rapamycin) for Extracranial Arteriovenous Malformations in Children and Adults.
Gabeff R, Boccara O, Soupre V, Lorette G, Bodemer C, Herbreteau D, Tavernier E, Maruani A.
Acta DermatoVenereologica. 99(12):1105-1109 (2019)

Chirurgie secondaire des craniosténoses et faciocraniosténoses.
Arnaud E, Haber SE, Paternoster G, James S, Khonsari H, Morisseau-Durand MP, Fauroux B, Viot-Blanc V, Couloigner V, Picard A, Cormier-Daire V, Robert M, Legros C, Zerah M, Meyer PH.
Annales de Chirurgie Plastique Esthétique 64(5-6):494-505 (2019)

Conservative management is effective in unicystic ameloblastoma occurring from the neonatal period: A case report and a literature review.
Morice A, Neiva C, Fabre M, Spina P, Jouenne F, Galliani E, Vazquez MP, Picard A.
Oral Surgery Oral Medicine Oral Pathology Oral Radiology S2212-4403(19)31415-4 (2019)


Ewing’s Sarcoma of the Head and Neck: Margins are not just for surgeons.
Bouaoud J, Temam S, Cozic N, Galmiche-Rolland L, Belhous K, Kolb F, Bidault F, Bolle S, Dumont S, Laurence V, Plantaz D, Tabone MD, Marec-Berard P, Quassemyar Q, Couloigner V, Picard A, Gomez-Brouchet A, Le Deley MC, Mahier-Ait Oukhatar C, Kadlub N, Gaspar N.
Cancer Medicine 7(12):5879-5888 (2018)

Prenatal diagnosis of unicystic ameloblastoma.
Fievet A, Blondiaux E, Dohna M, Neiva-Vaz C, Ducou le Pointe H, Garel C.
Diagnostic and Interventional Imaging. 99(2):119-120 (2018)

Injections d’acides hyaluroniques au niveau de visages atteints de malformations faciales. Étude préliminaire de l’assouplissement des zones cicatricielles et de l’amélioration esthétique.
Franchi G, Neiva-Vaz C, Picard A, Vazquez MP.
Annales de Chirurgie Plastique Esthétique 63(3):197-204 (2018)

Predictors of speech outcomes in children with Pierre Robin sequence.
Morice A, Renault F, Soupre V, Chapuis C, Trichet Zbinden C, Kadlub N, Giudice A, Vazquez MP, Picard A.
Journal of Cranio-Maxillofacial Surgery 46(3):479-484 (2018)

Severe macroglossia after posterior fossa and craniofacial surgery in children.
J Bouaoud, A Joly, A Picard, B Thierry, E Arnaud, S James, I Hennessy, B McGarvey, P Cairet, A Vecchione, E Vergnaud, C Duracher, R H Khonsari
International Journal of Oral and Maxillofacial Surgery 47(4):428-436 (2018)

Molecular and cellular characterizations of human cherubism: disease aggressiveness depends on osteoclast differentiation.
Kadlub, N., Sessiecq, Q., Mandavit, M., L’Hermine, A., Badoual, C., Galmiche, L., Berdal, A., Descroix, V., Picard, A. and Coudert, A.
Orphanet Journal of Rare Diseases, 13(1) (2018).

Targeted therapy in patients with PIK3CA-related overgrowth syndrome.
Venot Q, Blanc T, Rabia SH, Berteloot L, Ladraa S, Duong JP, Blanc E, Johnson SC, Hoguin C, Boccara O, Sarnacki S, Boddaert N, Pannier S, Martinez F, Magassa S, Yamaguchi J, Knebelmann B, Merville P, Grenier N, Joly D, Cormier-Daire V, Michot C, Bole-Feysot C, Picard A, Soupre V, Lyonnet S, Sadoine J, Slimani L, Chaussain C, Laroche-Raynaud C, Guibaud L, Broissand C, Amiel J, Legendre C, Terzi F, Canaud G.
Nature. 558(7711):540-546 (2018)

Quality of life and nasal splints after primary cleft lip and nose repair: Prospective assessment of information and tolerance.
Hennocq Q, Person H, Hachani M, Bertin H, Corre P, Gorbonosov V, Ivanov A, Khonsari RH.
Journal of Cranio-Maxillofacial Surgery 46(10):1783-1789 (2018)

Congenital fibroblastic connective tissue nevi: Unusual and misleading presentations in three infantile cases.
Bouaoud J, Fraitag S, Soupre V, Mitrofanoff M, Boccara O, Galliot C, Bodemer C, Picard A, Khonsari RH.
Pediatric Dermatology 35(5):644-650 (2018)

Contribution of the periosteum to mandibular distraction.
Debelmas A, Picard A, Kadlub N, Boisson J.
PLoS One. 13(6):e0199116 (2018)

Dental consequences of pterygomaxillary dysjunction during fronto-facial monobloc advancement with internal distraction for Crouzon syndrome.
Sicard L, Hounkpevi M, Tomat C, James S, Paternoster G, Khonsari RH, Arnaud E.
Journal of Cranio-Maxillofacial Surgery 46(9):1476-1479 (2018)

Melanotic neuroectodermal tumor of infancy (MNTI) of the head and neck: A French multicenter study.
Moreau A, Galmiche L, Minard-Colin V, Rachwalski M, Belhous K, Orbach D, Joly A, Picard A, Kadlub N.
Journal of Cranio-Maxillofacial Surgery 46(2):201-206 (2018)

Orbital volume and shape in Treacher Collins syndrome.
Levasseur J, Nysjö J, Sandy R, Britto JA, Garcelon N, Haber S, Picard A, Corre P, Odri GA, Khonsari RH.
Journal of Cranio-Maxillofacial Surgery 46(2):305-311 (2018)

Severity of Retrognathia and Glossoptosis Does Not Predict Respiratory and Feeding Disorders in Pierre Robin Sequence
Morice, A., Soupre, V., Mitanchez, D., Renault, F., Fauroux, B., Marlin, S., Leboulanger, N., Kadlub, N., Vazquez, M., Picard, A. and Abadie, V.
Frontiers in Pediatrics, 6 (2018)

Temporomandibular joint anomalies in pediatric craniofacial Gorham-Stout disease.
Galiay L, Simon F, Lévy R, Couloigner V, Donadieu J, Toubiana J, Blauwblomme T, Khonsari RH. (2018)
Journal of Cranio-Maxillofacial Surgery 46(8):1179-1184 (2018)

Pierre Robin sequence: A comprehensive narrative review of the literature over time.
Giudice, A., Barone, S., Belhous, K., Morice, A., Soupre, V., Bennardo, F., Boddaert, N., Vazquez, M., Abadie, V. and Picard, A.
Journal of Stomatology, Oral and Maxillofacial Surgery, 119(5), pp.419-428 (2018)

Pathogenesis of cranial neuropathies in Moebius syndrome: Electrodiagnostic orofacial studies.
Renault, F., Flores-Guevara, R., Sergent, B., Baudon, J., Aouizerate, J., Vazquez, M. and Gitiaux, C.
Muscle & Nerve, 58(1), pp.79-83 (2018)

Phenotypic spectrum of Tessier facial cleft number 5.
Racz C, Dakpé S, Kadlub N, Testelin S, Devauchelle B, Rachwalski M, Picard A.
Journal of Cranio-Maxillofacial Surgery 46(1):22-27 (2018)

Speech evaluation after intravelar veloplasty. How to use Borel-Maisonny classification in the international literature?
Kadlub N, Chapuis Vandenbogaerde C, Joly A, Neiva C, Vazquez MP, Picard A.
Journal of Stomatology, Oral and Maxillofacial Surgery 119(2):107-109 (2018)

Quantitative assessment of the learning curve for cleft lip repair using LC-CUSUM.
Segna E, Caruhel JB, Corre P, Picard A, Biau D, Khonsari RH.
International Journal of Oral and Maxillofacial Surgery 47(3):366-373 (2018)

Response to the Letter to the Editor regarding « Quantitative assessment of the learning curve for cleft lip repair using LC-CUSUM ».
Segna E, Khonsari RH.
International Journal of Oral and Maxillofacial Surgery 47(9):1226-1227 (2018)

A subperiosteal maxillary implant causing severe osteolysis.
Nguyen TM, Caruhel JB, Khonsari RH.
Journal of Stomatology, Oral and Maxillofacial Surgery 119(6):523-525 (2018)

Verrucous hemangioma (also known as verrucous venous malformation): A vascular anomaly frequently misdiagnosed as a lymphatic malformation.
Boccara O, Ariche-Maman S, Hadj-Rabia S, Chrétien-Marquet B, Frassati-Biaggi A, Zazurca F, Brunelle F, Soupre V, Bodemer C, Fraitag S.
Pediatric Dermatology 35(6):e378-e381 (2018)

Prenatal Diagnosis of a Melanotic Neuroectodermal Tumor of Infancy (MNTI): A Case Report With a Favorable Outcome After Chemotherapy Failure and Incomplete Resection.
Moreau A, Galmiche L, Belhous K, Franchi G, Couloigner V, Nevoux J, Antoine Aymard P, Picard A, Minard-Colin V, Kadlub N
Journal of Pediatric Hematology/Oncology 40(4):320-324 (2018)

Bilateral Dislocation of the Temporomandibular Joint in Children.
Sicard L, O’Hana D, Khonsari RH, Kaddour Brahim A.
Journal of Oral and Maxillofacial Surgery 76(11):2307-2315 (2018)

Familial autosomal dominant severe ankyloglossia with tooth abnormalities.
Lenormand A, Khonsari R, Corre P, Perrin JP, Boscher C, Nizon M, Pichon O, David A, Le Caignec C, Bertin H, Isidor B.
American Journal of Medical Genetics-Part A 176(7):1614-1617 (2018)

Minimally invasive versus standard approach in LeFort 1 osteotomy in patients with history of cleft lip and palate.
Séblain D, Bourlet J, Sigaux N, Khonsari RH, Chauvel Picard J, Gleizal A.
Journal of Stomatology, Oral and Maxillofacial Surgery 119(3):187-191 (2018)

Preoperative Detailed Coagulation Tests Are Required in Patients With Noonan Syndrome.
Morice A, Harroche A, Cairet P, Khonsari RH.
Journal of Oral and Maxillofacial Surgery 76(7):1553-1558 (2018)

Rhabdomyosarcoma and rhabdomyoma associated with nevoid basal cell carcinoma syndrome: Local treatment strategy.
Kerbrat A, Beaufrere A, Neiva-Vaz C, Galmiche L, Belhous K, Orbach D, Gauthier-Villars M, Picard A, Kadlub N.
Pediatric Dermatology 35(4):e245-e247 (2018)


Management of rare diseases of the Head, Neck and Teeth: results of a French population-based prospective 8-year study.
Friedlander L, Choquet R, Galliani E, de Chalendar M, Messiaen C, Ruel A, Vazquez MP, Berdal A, Alberti C, De La Dure Molla M.
Orphanet Journal of Rare Diseases, 12(1), p. 94-107 (2017)

Arterial Spin-Labeling to Discriminate Pediatric Cervicofacial Soft-Tissue Vascular Anomalies.
Boulouis G, Dangouloff-Ros V, Boccara O, Garabedian N, Soupre V, Picard A, Couloigner V, Boddaert N, Naggara O, Brunelle F.
American Journal of Neuroradiology 38(3):633-638 (2017)

Congenital Infantile Fibrosarcoma Associated With a Lipofibromatosis-Like Component: One Train May Be Hiding Another.
Swiadkiewicz R, Galmiche L, Belhous K, Boccara O, Fraitag S, Pedeutour F, Dadone B, Buis J, Picard A, Orbach D, Kadlub N.
American Journal of Dermatopathology 39(6):463-467 (2017)

Efficiency of prenatal diagnosis in Pierre Robin sequence.
Di Pasquo E, Amiel J, Roth P, Malan V, Lind K, Chalouhi C, Soupre V, Gordon CT, Lyonnet S, Salomon LJ, Abadie V.
Prenatal Diagnosis 37(11):1169-1175 (2017)

Familial lumps of the lower jaw.
Bouaoud J, Picard A, Joly A, Khonsari RH.
Journal of Stomatology, Oral and Maxillofacial Surgery 118(5):327-329

Mosaic-activating FGFR2 mutation in two fetuses with papillomatous pedunculated sebaceous naevus.
Kuentz P, Fraitag S, Gonzales M, Dhombres F, St-Onge J, Duffourd Y, Joyé N, Jouannic JM, Picard A, Marle N, Thevenon J, Thauvin-Robinet C, Faivre L, Rivière JB, Vabres P.
British Journal of Dermatology 176(1):204-208 (2017)

Contact information

Necker-Enfants malades university hospital
> Pediatric maxillofacial surgery and plastic surgery department

149 rue de Sèvres
75743 PARIS Cedex 15

> Pediatric welcome booklet

In Necker, the MAFACE refence center in brief 

patients followed at least once a year*
medical consultations*
day hospitalizations*
fully hospitalized patients*
authorized therapeutic education program*
patients trained in therapeutic education*
current research projects*
university courses*

* data valid for 2020