French national reference center for rare vascular diseases of the central nervous system and the retina (CERVCO)
The pediatric reference center for rare vascular diseases of the central nervous system and the retina (CERVCO) cares for rare vascular diseases of the brain and eye in children.
For neurovascular pathologies :
This center dedicated to rare diseases is based on a triple valence of pediatric neurology (Dr Manoëlle Kossorotoff), pediatric neurosurgery (Pr Thomas Blauwblomme) and pediatric diagnostic and interventional neuroradiology (Pr Olivier Naggara). It offers comprehensive care for patients referred for local consultation (Ile-de-France), second opinion or expert opinion. It has specialized pediatric neurological imaging and paraclinical examinations (MRI, cerebral arteriography), supported by inpatient neuropediatric and neurosurgical services, as well as an expert anesthesia-intensive care unit with pediatric operating and interventional theatres. Coordination with CERVCO’s coordinating adult center at Lariboisière and the sharing of CERVCO’s genetics platform dedicated to rare cerebrovascular diseases enable a cross-disciplinary vision of pathologies.
The center is very active in clinical research, focusing on aetiologies, prognostic factors, new imaging techniques and more.
For ophthalmic vascular pathologies :
The center draws on the expertise of the pediatric ophthalmology department, with its vascular referent (Dr. Alejandra Daruich), who has access to all the techniques needed to explore these rare diseases.
Competence centers network :
Competence centers for rare cerebrovascular diseases in children provide local follow-up. The centers in Paris-Bicêtre, Lille, Marseille, Lyon, Montpellier, Toulouse and Rennes have been accredited.
This reference center is affiliated with the Brain-Team rare diseases healthcare network.
On the occasion of world stroke day on October 29, 2021, Dr Manoëlle Kossorotoff provides an update on pediatric stroke.
What is a pediatric stroke? How to recognize it? Is it the same as in adults? What are the possible sequelae?
Find more videos on the pediatric stroke reference center page or on the Youtube channel.
Medical
team
Dr Manöelle Kossorotoff
MD, PhD
In case of emergency
The center has an expertise for the following diseases in children:
- Dr Manoëlle Kossorotoff, pediatric neurologist
- Pr Thomas Blauwblomme, neurosurgeon
- Pr Olivier Naggara, interventional neuroradiologist
- Kim Tran Dong, clinical research officer
Therapeutic education program for patients (children) with anticoagulation treatment at home, in the setting of thrombosis, excluding cardiac pathologies (cerebral venous thrombosis)
In collaboration with Dr Annie Harroche and the constitutional hemorrhagic diseases resource and competence center
- DREAM2 study (DREpAnocytosis and Cerebral Microcirculation: Multimodal exploration): Exploratory study of cerebral microcirculation in 60 children with sickle cell disease using a multimodal approach. Bicentric study, associate investigator, 2015-2018
- National PHRC « genetic and phenotypic spectrum of cerebral and retinal angiopathy associated with Col4A1 gene mutations », Investigator for the Necker-Enfants Malades site, 2009-2013
- Etiological genetic investigations of patients with moyamoya angiopathy (collaboration within the CERVCO network)
Interuniversity diploma in theoretical and practical training in neurovascular pathology and neurosonology option
Universities of Paris-Descartes, Paris-Pierre, Marie Curie, Paris-Diderot Dijon, Grenoble, Lille, Montpellier, Poitiers and Toulouse
Interuniversity diploma in diagnostic and therapeutic neurovascular imaging
Universities of Paris-Descartes, Nancy I, Lille II and Dijon
Interuniversity diploma in pediatric neurology
Universities of Paris-Descartes, Paris-Piette and Marie Curie, Aix-Marseille I, Paul Sabatier-Toulouse, Montpellier I, Paris-Sud, Aix-Marseille II, Reims-Champagne, Angers, Claude Bernard-Lyon I and Lille II
University degree in on-line teaching on sickle cell disease
Paris-Descartes university
2021
– Brain injury pathophysiology study by a multimodal approach in children with sickle cell anemia with no intra or extra cranial arteriopathy.
Brousse V, Pondarre C, Kossorotoff M, Arnaud C, Kamdem A, de Montalembert M, Boutonnat-Faucher B, Allali S, Bourdeau H, Charlot K, Bertil S, Da Costa L, Connes P, Grévent D, Verlhac S.
Haematologica. 2021 Apr 22. doi: 10.3324/haematol.2020.278226. Online ahead of print. PMID: 33882639
– Mortality and functional outcome after pediatric intracerebral hemorrhage: cohort study and meta-analysis.
Boulouis G, Stricker S, Benichi S, Hak JF, Gariel F, Kossorotoff M, Garcelon N, Harroche A, Alias Q, Garzelli L, Bajolle F, Boddaert N, Meyer P, Blauwblomme T, Naggara O.
J Neurosurg Pediatr. 2021 Apr 9:1-7. doi: 10.3171/2020.9.PEDS20608. Online ahead of print. PMID: 33836498
– Acute surgical management of children with ruptured brain arteriovenous malformation.
Stricker S, Boulouis G, Benichi S, Bourgeois M, Gariel F, Garzelli L, Hak JF, Alias Q, Kerleroux B, Beccaria K, Chivet A, de Saint Denis T, James S, Paternoster G, Zerah M, Kossorotoff M, Boddaert N, Brunelle F, Meyer P, Puget S, Naggara O, Blauwblomme T.
J Neurosurg Pediatr. 2021 Jan 22:1-9. doi: 10.3171/2020.8.PEDS20479. Online ahead of print. PMID: 33482644
– Hemorrhage Expansion After Pediatric Intracerebral Hemorrhage.
Boulouis G, Hak JF, Kerleroux B, Benichi S, Stricker S, Gariel F, Alias Q, Bourgeois M, Meyer P, Kossorotoff M, Garzelli L, Garcelon N, Boddaert N, Morotti A, Blauwblomme T, Naggara O.
Stroke. 2021 Jan;52(2):588-594. doi: 10.1161/STROKEAHA.120.030592. Epub 2021 Jan 11. PMID: 33423517
– Etiology of intracerebral hemorrhage in children: cohort study, systematic review, and meta-analysis.
Boulouis G, Stricker S, Benichi S, Hak JF, Gariel F, Alias Q, de Saint Denis T, Kossorotoff M, Bajolle F, Garzelli L, Beccaria K, Paternoster G, Bourgeois M, Garcelon N, Harroche A, Mancusi RL, Boddaert N, Puget S, Brunelle F, Blauwblomme T, Naggara O.
J Neurosurg Pediatr. 2021 Jan 1:1-7. doi: 10.3171/2020.7.PEDS20447. Online ahead of print. PMID: 33385999 Review.
– First Line Onyx Embolization in Ruptured Pediatric Arteriovenous Malformations : Safety and Efficacy.
Alias Q, Boulouis G, Blauwblomme T, Benichi S, Beccaria K, Gariel F, Garzelli L, Meyer P, Kossorotoff M, Boddaert N, Brunelle F, Naggara O.
Clin Neuroradiol. 2021 Mar;31(1):155-163. doi: 10.1007/s00062-019-00861-6. Epub 2019 Dec 4. PMID: 31802150
2020
– Risk Factors for Early Brain AVM Rupture: Cohort Study of Pediatric and Adult Patients.
Garzelli L, Shotar E, Blauwblomme T, Sourour N, Alias Q, Stricker S, Mathon B, Kossorotoff M, Gariel F, Boddaert N, Brunelle F, Meyer P, Naggara O, Clarençon F, Boulouis G.
AJNR Am J Neuroradiol. 2020 Dec;41(12):2358-2363. doi: 10.3174/ajnr.A6824. Epub 2020 Oct 29.PMID: 33122204
– Xq28 copy number gain causing moyamoya disease and a novel moyamoya syndrome.
Aloui C, Guey S, Pipiras E, Kossorotoff M, Guéden S, Corpechot M, Bessou P, Pedespan JM, Husson M, Hervé D, Riant F, Kraemer M, Steffann J, Quenez O, Tournier-Lasserve E.
J Med Genet. 2020 May;57(5):339-346. doi: 10.1136/jmedgenet-2019-106525. Epub 2020 Jan 10. PMID: 31924698
– The pleiotropy associated with de novo variants in CHD4, CNOT3, and SETD5 extends to moyamoya angiopathy.
Pinard A, Guey S, Guo D, Cecchi AC, Kharas N, Wallace S, Regalado ES, Hostetler EM, Sharrief AZ, Bergametti F, Kossorotoff M, Hervé D, Kraemer M, Bamshad MJ, Nickerson DA, Smith ER, Tournier-Lasserve E, Milewicz DM.
2019
– Nontraumatic Pediatric Intracerebral Hemorrhage.
Boulouis G, Blauwblomme T, Hak JF, Benichi S, Kirton A, Meyer P, Chevignard M, Tournier-Lasserve E, Mackay MT, Chabrier S, Cordonnier C, Kossorotoff M, Naggara O.
Stroke. 2019 Dec;50(12):3654-3661. doi: 10.1161/STROKEAHA.119.025783. Epub 2019 Oct 22. PMID: 31637968
2018
– Predictors of Outcome in Patients with Pediatric Intracerebral Hemorrhage: Development and Validation of a Modified Score.
Guédon, A., Blauwblomme, T., Boulouis, G., Jousset, C., Meyer, P., Kossorotof, M., Bourgeois, M., Puget, S., Zerah, M., Oppenheim, C., Meder, J., Boddaert, N., Brunelle, F., Sainte-Rose, C. and Naggara, O.
Radiology (2018), 286(2), pp.651-658
2017
– Moyamoya syndrome in children with neurofibromatosis type 1: Italian-French experience.
Santoro C, Di Rocco F, Kossorotoff M, Zerah M, Boddaert N, Calmon R, Vidaud D, Cirillo M, Cinalli G, Mirone G, Giugliano T, Piluso G, D’Amico A, Capra V, Pavanello M, Cama A, Nobili B, Lyonnet S, Perrotta S.
Am J Med Genet 2017;173:1521-30
– De novo mutations in CBL causing early-onset paediatric moyamoya angiopathy.
Guey S, Grangeon L, Brunelle F, Bergametti F, Amiel J, Lyonnet S, Delaforge A, Arnould M, Desnous B, Bellesme C, Hervé D, Schwitalla JC, Kraemer M, Tournier-Lasserve E, Kossorotoff M.
J Med Genet 2017;54:550-7
– Long-term Outcome After Multiple Burr Hole Surgery in Children With Moyamoya Angiopathy: A Single-Center Experience in 108 Hemispheres.
Blauwblomme, T., Mathon, B., Naggara, O., Kossorotoff, M., Bourgeois, M., Puget, S., Meyer, P., Brousse, V., de Montalembert, M., Brunelle, F., Zerah, M. and Sainte-Rose, C.
2016
– Cerebral Blood Flow Improvement after Indirect Revascularization for Pediatric Moyamoya Disease: A Statistical Analysis of Arterial Spin-Labeling MRI.
Blauwblomme, T., Lemaitre, H., Naggara, O., Calmon, R., Kossorotoff, M., Bourgeois, M., Mathon, B., Puget, S., Zerah, M., Brunelle, F., Sainte-Rose, C. and Boddaert, N.
American Journal of Neuroradiology (2016), 37(4), pp.706-712
2015
– Cerebral haemorrhagic risk in children with sickle-cell disease.
Kossorotoff M, Brousse V, Grevent D, Naggara O, Brunelle F, Blauwblomme T, Gaussem P, Desguerre I, De Montalembert M.
Dev Med Child Neurol 2015;57:187-93
Pediatric stroke – Dr Kossorotoff
What is a pediatric stroke? How to recognize it? Is it the same as in adults? What are the possible sequelae?
Contact information
Necker-Enfants malades university hospital
> Pediatric neurology department
149 rue de Sèvres
75743 PARIS Cedex 15
In Necker, the reference center for rare vascular diseases of the central nervous system and the retina (CERVCO) in brief …
* data valid for 2022