RAISE English

French national reference center for inflammatory rheumatic diseases, autoimmune diseases and systemic interferonopathies in children (RAISE)

RAISE is a national reference center for inflammatory pathologies in the fields of paediatric rheumatology, including juvenile idiopathic arthritis (JIA), JIA-associated chronic uveitis, systemic vasculitis, connective tissue diseases (juvenile lupus and dermatomyositis in particular), and monogenic or complex autoinflammatory diseases including systemic granulomatoses and monogenic interferonopathies in children.

Its missions are to assist in the management and information of patients and families, in connection with associations and the network of reference and competence centers. The center coordinates or participates in several research programs in the field of pediatric rheumatology and systemic inflammatory pathologies. The center is coordinated by professor Pierre Quartier-dit-Maire, with Doctors Brigitte Bader-Meunier, Marie-Louise Frémond and Benjamin Fournier in the unit of pediatric immunology, hematology and rheumatology of the Necker-Enfants Malades university hospital.

Logo FAI2RThis reference center is affiliated with the FAI²R rare diseases healthcare network  Logo ERN RITAand the RITA European reference network (ERN).

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Keywords : juvenile arthritis, Still disease, chronic non-infectious uveitis, pediatric vasculitis, connective tissue disease, lupus, juvenile dermatomyositis, auto-inflammatory syndromes, granulomatosis, monogenic interferonopathies, biotherapies and other innovative therapeutics. 

Vignette Adolupus RAISE

Adolupus platform : This website is intended for teenagers and young adults with lupus and aims to help them understand systemic lupus, live with the disease and take action on a daily basis.


Pr Pierre Quartier-dit-Maire


Dr Brigitte Bader-Meunier


Contact us

Phone. 01 44 49 48 28 / 43 32

> Send an email

In case of emergency

  • Systemic form of juvenile idiopathic arthritis
  • Polyarticular form of juvenile idiopathic arthritis with rheumatoid factor
  • Polyarticular form of juvenile idiopathic arthritis without rheumatoid factor
  • Juvenile idiopathic oligoarthritis (of which about 20% with chronic uveitis)
  • Juvenile idiopathic arthritis associated with psoriasis
  • Enthesitis related to juvenile idiopathic arthritis
  • Ungroupable juvenile idiopathic arthritis
  • Pediatric-onset systemic lupus erythematosus
  • Juvenile dermatomyositis
  • Juvenile overlap connectivitis
  • Juvenile systemic scleroderma
  • Pediatric-onset systemic vasculitis
  • Familial Mediterranean fever
  • Hyper-IgD syndrome / partial mevalonate kinase deficiency
  • Cryopyrinopathies (CINCA and Muckle-Wells syndromes)
  • Other rare autoinflammatory syndromes
  • Interferonopathies with autoimmune and / or auto-inflammatory expression
En savoir +

  • Pr Pierre Quartier-dit-Maire, pediatric rheumatologist – head of the CRMR
  • Dr Brigitte Bader-Meunier, pediatric rheumatologist
  • Dr Marie-Louise Frémond, pediatric rheumatologist
  • Dr Richard Mouy, pediatric rheumatologist
  • Pr Bénédicte Neven, pediatric rheumatologist
  • Pr Carine Wouters, pediatric rheumatologist
  • Dr Chantal Job-Deslandre, pediatric rheumatologist
  • Dr Florence Uettwiller, pediatric rheumatologist
  • Dr Isabelle Melki, pediatric rheumatologist
  • Dr Florence Aeschlimann, pediatric rheumatologist
  • Pr Christophe Glorion, consultant specialist in orthopedic surgery
  • Pr Christine Bodemer, consultant specialist in dermatology
  • Pr Rémi Salomon, consultant specialist in nephrology
  • Dr Sylvain Breton, consultant specialist in radiology
  • Dr Frank Ruemmele, consultant specialist in gastroenterology
  • Pr Valérie Cormier-Daire, consultant specializing in constitutional bone diseases
  • Dr Geneviève Baujat, consultant specialist in constitutional bone diseases
  • Dr Cyril Gitiaux, consultant specialist in neuro-muscular diseases
  • Dr Céline Greco, consultant specialist in pain management
  • Dr Alice Hadchouel, consultant specialist pneumology
  • Elsa Saire, physiotherapist
  • Fanny Léopole-dit-Marie, physiotherapist
  • Elodie Deladrière, occupational therapist
  • Virginie Germat, occupational therapist
  • Thao Truong, clinical research officer
  • Phédra Figoni, secretary
  • Dorothée Soussana, secretary

Juvenile idiopathic arthritis

  • Adalimumab versus placebo in childhood anterior uveitis randomized trial
  • Identification of genetic causes of pediatric-onset systemic lupus
  • Identification of factors of gravity and search for new therapeutic targets in dermatomyositis in children

Interuniversity diploma in pediatric rheumatology
Paris-Descartes university, Lyon I university


Tapering Canakinumab Monotherapy in Patients With Systemic Juvenile Idiopathic Arthritis in Clinical Remission: Results From a Phase IIIb/IV Open-Label, Randomized Study.
Pierre Quartier, Ekaterina Alexeeva, Tamàs Constantin, Vyacheslav Chasnyk, Nico Wulffraat, Karin Palmblad, Carine Wouters, Hermine I Brunner, Katherine Marzan, Rayfel Schneider
Arthritis Rheumatol, 2021 Feb, PMID: 32783351 PMCID: PMC7898684 DOI: 10.1002/art.41488

COPA syndrome, 5 years after: Where are we?
Marie-Louise Frémond, Nadia Nathan
Joint Bone Spine, 2021 Mar, PMID: 32919065 DOI: 10.1016/j.jbspin.2020.09.002

Overview of STING-Associated Vasculopathy with Onset in Infancy (SAVI) Among 21 Patients.
Marie-Louise Frémond, Alice Hadchouel, Laureline Berteloot, Isabelle Melki, Violaine Bresson, Laura Barnabei, Nadia Jeremiah, Alexandre Belot, Vincent Bondet et al.
J Allergy Clin Immunol Pract, 2021 Feb, PMID: 33217613 DOI: 10.1016/j.jaip.2020.11.007

Differential Expression of Interferon-Alpha Protein Provides Clues to Tissue Specificity Across Type I Interferonopathies.
Lorenzo Lodi, Isabelle Melki, Vincent Bondet, Luis Seabra, Gillian I Rice, Edwin Carter, Alice Lepelley, Maria José Martin-Niclós, Buthaina Al Adba, Brigitte Bader-Meunier et al.
J Clin Immunol, 2021 Apr, PMID: 33411153 DOI: 10.1007/s10875-020-00952-x

STING-Mediated Lung Inflammation and Beyond.
Marie-Louise Frémond, Yanick J Crow
J Clin Immunol, 2021 Apr, PMID: 33532887 DOI: 10.1007/s10875-021-00974-z

JAK inhibitors are effective in a subset of patients with juvenile dermatomyositis: a monocentric retrospective study.
Tom Le Voyer, Cyril Gitiaux, François-Jérôme Authier, Christine Bodemer, Isabelle Melki, Pierre Quartier, Florence Aeschlimann, Arnaud Isapof, Jean Philippe Herbeuval et al.
Rheumatology (Oxford), 2021 Dec 1, PMID: 33576769 DOI: 10.1093/rheumatology/keab116

Evaluation of Hydroxychloroquine Blood Concentrations and Effects in Childhood-Onset Systemic Lupus Erythematosus.
Noël Zahr, Saik Urien, Christian Funck-Brentano, Hélène Vantomme, Nicolas Garcelon, Isabelle Melki, Margaux Boistault, Olivia Boyer, Brigitte Bader-Meunier
Pharmaceuticals (Basel), 2021 Mar 17, PMID: 33802811 PMCID: PMC8002378 DOI: 10.3390/ph14030273

Rheumatoid factor positive polyarticular juvenile idiopathic arthritis associated with a novel COPA mutation.
Brigitte Bader-Meunier, Marta Bustaffa, Thinhinane Iskounen, Edwin Carter, Joseph A Marsh, Geneviève Baujat, Yanick J Crow, Marie-Louise Frémond
Rheumatology (Oxford), 2021 May 14, PMID: 33877315 DOI: 10.1093/rheumatology/keaa763

Juvenile Idiopathic Arthritis-Associated Chronic Uveitis: Recent Therapeutic Approaches.
Pierre Quartier
J Clin Med, 2021 Jun 30, PMID: 34208973 PMCID: PMC8269439 DOI: 10.3390/jcm10132934

JAK inhibition in the type I interferonopathies.
Yanick J Crow, Bénédicte Neven, Marie-Louise Frémond
J Allergy Clin Immunol, 2021 Oct, PMID: 34375617 DOI: 10.1016/j.jaci.2021.07.028

A young girl with severe polyarteritis nodosa successfully treated with tocilizumab: a case report.
Margaux Boistault, Mireia Lopez Corbeto, Pierre Quartier, Laura Berbel Arcobé, Ariadna Carsi Durall, Florence A Aeschlimann
Pediatr Rheumatol Online J, 2021 Dec 3, PMID: 34861842 PMCID: PMC8641167 DOI: 10.1186/s12969-021-00654-7

Myocardial involvement in children with post-COVID multisystem inflammatory syndrome: a cardiovascular magnetic resonance based multicenter international study-the CARDOVID registry.
Florence A Aeschlimann, Nilanjana Misra, Tarique Hussein, Elena Panaioli, Jonathan H Soslow, Kimberly Crum, Jeremy M Steele, Steffen Huber, Simona Marcora, Paolo Brambilla et al.
J Cardiovasc Magn Reson, 2021 Dec 30, PMID: 34969397 PMCID: PMC8717054 DOI: 10.1186/s12968-021-00841-1


Comment on: Monogenic mimics of Behçet »s disease in the young.
Florence A Aeschlimann, Marie-Claude Stolzenberg, Frédéric Rieux-Laucat, Marta Bustaffa, Pierre Quartier, Stanislas Lyonnet, Serge Romana, Brigitte Bader-Meunier
Rheumatology (Oxford), 2020 Nov 1, PMID: 31725163 DOI: 10.1093/rheumatology/kez543

Comment on: Monogenic mimics of Behçet »s disease in the young.
Florence A Aeschlimann, Marie-Claude Stolzenberg, Frédéric Rieux-Laucat, Marta Bustaffa, Pierre Quartier, Stanislas Lyonnet, Serge Romana, Brigitte Bader-Meunier
Rheumatology (Oxford), 2020 Nov 1, PMID: 31725163 DOI: 10.1093/rheumatology/kez543

Severe Abdominal Manifestations in Juvenile Dermatomyositis.
Caroline Besnard, Cyril Gitiaux, Muriel Girard, Louise Galmiche-Rolland, Cécile Talbotec, Pierre Quartier, Christine Bodemer, Laureline Berteloot, Brigitte Bader-Meunier
J Pediatr Gastroenterol Nutr, 2020 Feb, PMID: 31978027 DOI: 10.1097/MPG.0000000000002575


Chronic and recurrent non-infectious paediatric-onset uveitis: a French cohort.
Guillaume Morelle, Julie Gueudry, Florence Uettwiller, Carine Wouters, Brigitte Bader-Meunier, Mathieu P Robert, Dominique Monnet, Bahram Bodaghi, Martine Grall-Lerosey, Pierre Quartier
RMD Open, 2019 Aug 5, PMID: 31452929 PMCID: PMC6691513 DOI: 10.1136/rmdopen-2019-000933

[Juvenile idiopathic arthritis].
Florence A Aeschlimann, Pierre Quartier
Rev Prat, 2019 Feb, PMID: 30983224

Anakinra in children and adults with Still »s disease.
Sebastiaan J Vastert, Yvan Jamilloux, Pierre Quartier, Sven Ohlman, Lisa Osterling Koskinen, Torbjörn Kullenberg, Karin Franck-Larsson, Bruno Fautrel, Fabrizio de Benedetti
Rheumatology (Oxford), 2019 Nov 1, PMID: 31769856 PMCID: PMC6878842 DOI: 10.1093/rheumatology/kez350

Risk of Serious Infections Associated with Biologic Agents in Juvenile Idiopathic Arthritis: A Systematic Review and Meta-Analyses.
Florence A Aeschlimann, Shu-Ling Chong, Todd W Lyons, Beate C Beinvogl, Lina Maria Góez-Mogollón, Sally Tan, Ronald M Laxer
J Pediatr, 2019 Jan, PMID: 30318371 DOI: 10.1016/j.jpeds.2018.08.065

Presentation and Disease Course of Childhood-Onset Versus Adult-Onset Takayasu Arteritis.
Florence A. Aeschlimann MD, MPH, Lillian Barra MD, MPH, Roaa Alsolaimani MD, Susanne M. Benseler MD, PhD, Diane Hebert MD, Nader Khalidi MD, Ronald M. Laxer MD, Damien Noone MB, BCh, BAO, MSc, Christian Pagnoux MD, MPH, Marinka Twilt MD, PhD, Rae S. M. Yeung MD, PhD
Arthritis Rheumatol, 2019 Feb, PMID: 30101446 DOI: 10.1002/art.40690

Etanercept concentration and immunogenicity do not influence the response to Etanercept in patients with juvenile idiopathic arthritis.
Brigitte Bader-Meunier, Roman Krzysiek, Irène Lemelle, Christine Pajot, Aurélia Carbasse, Sylvaine Poignant, Isabelle Melki, Pierre Quartier, Laure Choupeaux, Elodie Henry, Jean-Marc Treluyer, Alexandre Belot, Salima Hacein-Bey-Abina, Saik Urien
Semin Arthritis Rheum, 2019 Jun, PMID: 30396593 DOI: 10.1016/j.semarthrit.2018.09.002

French expert opinion for the management of juvenile dermatomyositis.
B Bader-Meunier, C Gitiaux, A Belot, K Brochard, R Mouy, D Ponce, V Bughin, F Jouen, L Musset, Y Allenbach, E Hachulla, H Maillard, A Meyer, E Bourrat, O Benveniste, French Network of rare autoimmune, autoinflammatory diseases FAI2R
Arch Pediatr, 2019 Feb, PMID: 30638764 DOI: 10.1016/j.arcped.2018.12.002

Comment on: ‘Aberrant tRNA processing causes an autoinflammatory syndrome responsive to TNF inhibitors’ by Giannelou et al: mutations in TRNT1 result in a constitutive activation of type I interferon signalling
Marie-Louise Frémond, Isabelle Melki, Sven Kracker, Vincent Bondet, Darragh Duffy, Gillian I Rice, Yanick J Crow, Brigitte Bader-Meunier
Ann Rheum Dis, 2019 Aug, PMID: 29858171 DOI: 10.1136/annrheumdis-2018-213745


ADJUVITE: a double-blind, randomised, placebo-controlled trial of adalimumab in early onset, chronic, juvenile idiopathic arthritis-associated anterior uveitis.
Quartier P, Baptiste A, Despert V, Allain-Launay E, Koné-Paut I, Belot A, Kodjikian L, Monnet D, Weber M, Elie C, Bodaghi B; ADJUVITE Study Group.
Ann Rheum Dis. 2018 Jul, PMID: 29275333 DOI: 10.1136/annrheumdis-2017-212089

Childhood- versus Adult-Onset Polyarteritis Nodosa Results from the French Vasculitis Study Group Registry.
Iudici M, Quartier P, Pagnoux C, Merlin E, Agard C, Aouba A, Roblot P, Cohen P, Terrier B, Mouthon L, Guillevin L, Puéchal X; French Vasculitis Study Group.
Autoimmun Rev. 2018, PMID: 30114520 DOI: 10.1016/j.autrev.2018.08.001

Canakinumab for the Treatment of Autoinflammatory Recurrent Fever Syndromes.
De Benedetti F, Gattorno M, Anton J, Ben-Chetrit E, Frenkel J, Hoffman HM, Koné-Paut I, Lachmann HJ, Ozen S, Simon A, Zeft A, Calvo Penades I, Moutschen M, Quartier P, Kasapcopur O, Shcherbina A, Hofer M, Hashkes PJ, Van der Hilst J, Hara R, Bujan-Rivas S, Constantin T, Gul A, Livneh A, Brogan P, Cattalini M, Obici L, Lheritier K, Speziale A, Junge G.
N Engl J Med. 2018 May 17; PMID: 29768139 DOI: 10.1056/NEJMoa1706314

Inherited Immunodeficiency: A New Association With Early-Onset Childhood Panniculitis.
Bader-Meunier B, Rieux-Laucat F, Touzot F, Frémond ML, André-Schmutz I, Fraitag S, Bodemer C. Pediatrics, 2018 Apr, PMID: 29610179 DOI: 10.1542/peds.2017-0213


Type I interferon-mediated autoinflammation due to DNase II deficiency.
Rodero MP, Tesser A, Bartok E, Rice GI, Della Mina E, Depp M, Beitz B, Bondet V, Cagnard N, Duffy D, Dussiot M, Frémond ML, Gattorno M, Guillem F, Kitabayashi N, Porcheray F, Rieux-Laucat F, Seabra L, Uggenti C, Volpi S, Zeef LAH, Alyanakian MA, Beltrand J, Bianco AM, Boddaert N, Brouzes C, Candon S, Caorsi R, Charbit M, Fabre M, Faletra F, Girard M, Harroche A, Hartmann E, Lasne D, Marcuzzi A, Neven B, Nitschke P, Pascreau T, Pastore S, Picard C, Picco P, Piscianz E, Polak M, Quartier P, Rabant M, Stocco G, Taddio A, Uettwiller F, Valencic E, Vozzi D, Hartmann G, Barchet W, Hermine O, Bader-Meunier B, Tommasini A, Crow YJ.
Nat Commun. 2017 Dec 19, PMID: 29259162 PMCID: PMC5736616 DOI: 10.1038/s41467-017-01932-3

European evidence-based recommendations for diagnosis and treatment of paediatric antiphospholipid syndrome: the SHARE initiative.
Groot N, de Graeff N, Avcin T, Bader-Meunier B, Dolezalova P, Feldman B, Kenet G, Koné-Paut I, Lahdenne P, Marks SD, McCann L, Pilkington CA, Ravelli A, van Royen-Kerkhof A, Uziel Y, Vastert SJ, Wulffraat NM, Ozen S, Brogan P, Kamphuis S, Beresford MW.
Ann Rheum Dis. 2017 Oct, PMID: 28630236 DOI: 10.1136/annrheumdis-2016-210960

Site Adolupus Raise

Adolupus platform : Website is intended for teenagers and young adults with lupus and aims to help them understand systemic lupus, live with the disease and take action on a daily basis.

Contact information

Necker-Enfants malades university hospital
> Pediatric immunology, hematology and rheumatology department

149 rue de Sèvres
75743 PARIS Cedex 15

In Necker, the RAISE reference center in brief 

patients followed at least once a year*
medical consultations*
day hospitalizations*
fully hospitalized patients*
authorized therapeutic education programs*
patient trained in therapeutic education*
teleconsultation procedures*
current research projects*
university courses*

* data valid for 2022