Pulmonary hypertension

French national reference center for pulmonary hypertension

The rare diseases reference center treats patients suffering from severe pulmonary hypertension. It is part of a network of 7 reference centers and 22 competence centers.

The pulmonary hypertension reference center at Necker-Enfants malades University hospital is the only pediatric reference center for all types of pulmonary hypertension. These include newborns, children and adolescents.

The Necker pediatric site is equipped with the full range of diagnostic facilities for pulmonary hypertension. It plays an active role in therapeutic innovation in pediatric pulmonary arterial hypertension, coordinating the majority of therapeutic trials in France. It has a full range of techniques for treating the most severe forms, including Potts anastomosis and lung transplantation.

Logo respifilThis reference center is affiliated to the RESPIFIL rare diseases healthcare network andLogo ERN-LUNG the LUNG European reference network (ERN).

> Find out more             

Keywords : Pulmonary hypertension, PAH, children, lung transplantation, genetics


Professeur Damien Bonnet

Pr Damien Bonnet

Contact us

Phone. 01 44 49 43 44

> Send an email

In case of emergency

  • Pr Damien Bonnnet, cardiologist: head of the reference center
  • Isabelle Szezepanski, clinical research assistant pulmonary hypertension
  • Dr Marilyne Lévy, cardiologist : pulmonary hypertension
  • Pr Olivier Raisky, cardiac surgery, lung transplantation

Pulmonary arterial hypertension and congenital heart disease in children

Heart failure and congenital heart disease in children

Adolescent-adulthood transition

Cardiac pacemakers and defibrillators in children

Antivitamin K in children

  • Congenital heart diseases Itinerair register : epidemiology and care of pulmonary hypertension in congenital heart diseases
  • TOPP international register
  • Genetics of pulmonary hypertensions in children
  • Treprostinil, selexipag, sotatercept therapeutic trials
  • Pulmonary hypertension with venous component

University diploma in pediatric cardiology
University of Paris

Inter-university diploma in congenital and pediatric cardiology
University of Paris, Lille II university and university of Lyon

Inter-university diploma in surgical resuscitation of congenital heart disease
University of Paris and Bordeaux II university

Inter-university diploma in congenital heart disease surgery
University of Paris, university of Bordeaux, university of Marseille and university of Lyon


Application of a modified clinical classification for pulmonary arterial hypertension associated with congenital heart disease in children: emphasis on atrial septal defects and transposition of the great arteries. An analysis from the TOPP registry.
Wacker J, Humpl T, Berger RMF, Ivy D, Bowers D, Bonnet D, Beghetti M.
Front Cardiovasc Med. 2024 Feb 2;11:1344014. doi: 10.3389/fcvm.2024.1344014. PMID: 38370158; PMCID: PMC10870771.


Monitoring of Hemodynamics With Right Heart Catheterization in Children With Pulmonary Arterial Hypertension.
Grynblat J, Malekzadeh-Milani SG, Meot M, Perros F, Szezepanski I, Morisset S, Ovaert C, Bonnet C, Maragnes P, Ranchoup J, Humbert M, Montani ID, Levy M, Bonnet D.
J Am Heart Assoc. 2023 Apr 4;12(7):e029085.

Long-term Outcome of Children with Newly Diagnosed Pulmonary Arterial Hypertension: Results From the Global TOPP-registry.
Ploegstra MJ, Ivy DD, Beghetti M, Bonnet D, Alehan D, Ablonczy L, Mattos S, Bowers D, Humpl T, Berger RMF; TOPP Investigators.
Eur Heart J Qual Care Clin Outcomes. 2023 Mar 27:qcad020.


Safety and Feasibility of the Transcatheter Approach to Create a Reverse Potts Shunt in Children With Idiopathic Pulmonary Arterial Hypertension.
Boudjemline Y, Sizarov A, Malekzadeh-Milani S, Mirabile C, Lenoir M, Khraiche D, Lévy M, Bonnet D.
Can J Cardiol 2017;33:1188-1196.


Growth in children with pulmonary arterial hypertension: a longitudinal retrospective multiregistry study.
Ploegstra MJ, Ivy DD, Wheeler JG, Brand M, Beghetti M, Rosenzweig EB, Humpl T, Iriart X, Rouzic EM, Bonnet D, Berger RM.
Lancet Respir Med 2016 ; 4:281-90.

To « Cath » or Not in Pediatric Pulmonary Hypertension?
Beghetti M, Berger RM, Ivy DD, Bonnet D, Humpl T.
J Am Coll Cardiol 2016;67:1010-1.

Executive summary. Expert consensus statement on the diagnosis and treatment of paediatric pulmonary hypertension. The European Paediatric Pulmonary Vascular Disease Network, endorsed by ISHLT and DGPK.
Hansmann G, Apitz C, Abdul-Khaliq H, Alastalo TP, Beerbaum P, Bonnet D, Dubowy KO, Gorenflo M, Hager A, Hilgendorff A, Kaestner M, Koestenberger M, Koskenvuo JW, Kozlik-Feldmann R, Kuehne T, Lammers AE, Latus H, Michel-Behnke I, Miera O, Moledina S, Muthurangu V, Pattathu J, Schranz D, Warnecke G, Zartner P.
Heart 2016;102 Suppl 2:ii86-ii100.

Genetic analyses in a cohort of children with pulmonary hypertension.
Levy M, Eyries M, Szezepanski I, Ladouceur M, Nadaud S, Bonnet D, Soubrier F.
Eur Respir J 2016 ;48 :1118-1126.

Contact information

Necker-Enfants malades university hospital
> Cardiology department

149 rue de Sèvres
75743 PARIS Cedex 15

> Pediatric welcome booklet

In Necker, the reference center for pulmonary hypertension in brief 

patients followed at least once a year*
medical consultations*
day hospitalizations*
fully hospitalized patients*
authorized therapeutic education program*
patients trained in therapeutic education*
current research projects*
hours of university teaching*

* data valid for 2022